The museum is headquartered in the former Governor's Palace, a historicist edifice and protected cultural monument. The Governor's Palace was constructed in 1896 and designed by Alajos Hauszmann, one of the foremost Hungarian architects during the time when Rijeka was under Hungarian rule.
Today, the palace houses the Maritime and History Museum of the Croatian Littoral, which was established in 1961 and comprises maritime, historical and cultural, ethnographic and archaeological departments. Some of the original items from the Governor's Palace, such as furniture and artisan craft-work, have been preserved and exhibited in salons on the first floor. The permanent exhibition of the museum provides an interactive and modern platform for showcasing the long, rich and tumultuous history and culture of living in the area of what is today Primorje-Gorski Kotar County from prehistoric times to the present day.
The Lipa Pamti Memorial Centre (Lipa Remembers), which is dedicated to the victims of the Lipa massacre that took place on 30 April 1944, is also a part of the museum. In addition to its memorial heritage, the Memorial Centre interprets the entire cultural, historical and ethnographical heritage of the Liburnian Karst region (Rupa, Pasjak, Šapjane and Brce) from prehistoric times to the present day.